Nanoscale assessment of Toxins‐Cells Interactions by Atomic Force Spectroscopy

For this PostDoctoral position, the candidate will specifically use Atomic Force Microscopy in both imaging and force spectroscopy modes to quantify, at the molecular scale, the specific interactions operating between selected toxins produced by Biomphalaria glabrata and/or Schistosoma mansoni and their most relevant cellular targets, i.e. synthetic surfaces coated with purified receptors (lipids, polysaccharides, proteins), and living bacteria or blood cells. The candidate will also address the change in the morphology and nanomechanical properties of the targeted cells after their incubation with toxins using nano‐indentation Atomic Force Microscopy, possibly complemented by Confocal Microscopy and Holotomography measurements.
The candidate will be located in the Laboratoire Interdisciplinaire des Environnements Continentaux
(LIEC, https://liec.univ‐ in the group ’Physical Chemistry and Reactivity of Surfaces And
interfaces’’ with renown expertise in Atomic force Spectroscopy and Surface Biophysics.


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