Context
With the development of new quantitative methods, the microscope is one of the essential tools for research in cell biology, developmental biology, physiology,… These advances contribute to the understanding and quantification at different scales from the archaic prokaryote to Humans. They are supported by a broad interdisciplinary community constituted by physicists, chemists, biologists, instrumentalists, computer scientists, mathematicians and clinicians. This community carries out fundamental research at the interface between photon and living matter and the creation of new analysis and quantification tools. Developments in imaging are increasingly decisive and rapid, minimally invasive and adaptable to molecular study in living organisms. These developments must be accompanied and supported by a continuous effort to transfer knowledge and know-how and train beneficiaries in biology and medicine.
Contents
MiFoBio is a multidisciplinary school focusing on biological and technological advances for life imaging and quatification. The implementation of these techniques and their subsequent use to analyse the dynamic organisation of life requires the coupling of a complete set of know-how: from molecular and cellular biology, chemistry for the synthesis of molecular probes, optics, physics for the development of instrumentation and light sources, computing for the acquisition, analysis and storage of images, and finally methods for modelling and interpreting these measurements. Microscopy and combined imaging techniques, image analysis and results modeling constitute a continuum of knowledge and know-how that are the core of this school.
Organization
MiFoBio school unique and original format that is composed of lectures, round tables and experimental workshops with living biological material on various topics. In addition to very high level teaching lecturers, MiFoBio has an exceptional instrumental collection that allows it to carry out a large number of experimental workshops led by the scientists themselves. More than 100 different workshops will cover a wide range of biological topics (signaling, transcription, embryonic development, signal transduction, mechanobiology, metabolism and using the most advanced technologies in the field (ultra-high resolution, light sheet, adaptive optics, non-linear optics, correlative microscopy,…). The aims is to propose a real temporary interdisciplinary laboratory, which offers participants an understanding of biological issues, experimental practices, the use of different imageries, the use of quantitative data analysis methods and their modelling.
Program themes
– Marking strategies, probes and contrasts
– The challenge of quantification in nanoscopy
– Artificial intelligence for biological imaging
– Multicellular imaging: organoids, tissues, embryos
– Molecular dynamics and interactions in living cells
– Cellular signaling, mechanobiology, mechanotransduction
– Waves on living organisms
